By definition, clodronate liposome is a drug delivered using liposome (a synthetic lipid that encapsulates other substances for ease of administration into the body). Liposome is manly a medium which carries the highly hydrophilic Clodronate thus facilitating its transport into the target organ. Essentially, the aim of this type of drug administration is to achieve higher macrophage depletion after an intravenous injection of the drug.
The idea behind this drug is mainly to use it as the carrier or Trojan horse to help administer drugs that would not easily reach the target organ in normal cases. Provided the liposome has been ingested and digested by the macrophages (in the spleen for instance), the Clodronate is released into the organ though intracellular activities. The resultant product is the effective bisphosphonates that can then stop the macrophage functions.
Though still in the trial stages, the drug has shown a lot of success and will help in the treatment of cancer, osteoporosis and autoimmune hemolytic anemia. Metastatic carcinoma of the breast and multiple myeloma are among other conditions that the drug will be able to handle. On the other hand, this drug has shown success with the suppression of macrophage activities in neurological disorders, gene therapy and transplantation.
As with every most bisphosphonates, there are no major side effects associated with Clodronate. In fact, it is expected to have similar effects that other drugs in this category have shown. For instance, those undergoing treatment against high calcium levels in the blood do complain of mild stomach pains, nausea and vomiting. Other mild side effects include diarrhea and loss of appetite.
Apart from loss of appetite, the other complications include heavy breathing, hives and skin rashes. Though some of these may not need one to see a doctor, the cases of difficulty in breathing certainly does require the attention of one. You should therefore not hesitate to report to your physician for help if the side effects take longer than normal.
Other adverse drug reactions that might be associated with this drug include mouth pain, swelling and unexplainable tiredness or weakness. Moreover, patients who develop skin rashes and hives or severe muscle cramps after taking Clodronate should seek medical attention as a matter of urgency. Since these are just pre-release precautions, one should not be discouraged, as the final product may be a very stable product with lesser side effects.
Some general contraindications are common with most prescription drugs. For instance, you should not take the drug if you are allergic to Clodronates or bisphosphonates. Similarly, expecting or breastfeeding mothers should not use the drug. Patients with kidney problems or using other bisphosphonate drugs should not use the drug too. It is also advisable that you stay from these types of drugs if you have inflammation of the gastro intestines.
The use of clodronate liposome, like any other prescription medicine, should be a strict procedure. You are therefore not allowed to share it with other patients even if you suffer from the same disease. Additionally, you are not to borrow such drugs unless a qualified doctor prescribes them. Finally and yet importantly, you have to take the full dose without skipping if significant progress or complete healing is to be realized.
The idea behind this drug is mainly to use it as the carrier or Trojan horse to help administer drugs that would not easily reach the target organ in normal cases. Provided the liposome has been ingested and digested by the macrophages (in the spleen for instance), the Clodronate is released into the organ though intracellular activities. The resultant product is the effective bisphosphonates that can then stop the macrophage functions.
Though still in the trial stages, the drug has shown a lot of success and will help in the treatment of cancer, osteoporosis and autoimmune hemolytic anemia. Metastatic carcinoma of the breast and multiple myeloma are among other conditions that the drug will be able to handle. On the other hand, this drug has shown success with the suppression of macrophage activities in neurological disorders, gene therapy and transplantation.
As with every most bisphosphonates, there are no major side effects associated with Clodronate. In fact, it is expected to have similar effects that other drugs in this category have shown. For instance, those undergoing treatment against high calcium levels in the blood do complain of mild stomach pains, nausea and vomiting. Other mild side effects include diarrhea and loss of appetite.
Apart from loss of appetite, the other complications include heavy breathing, hives and skin rashes. Though some of these may not need one to see a doctor, the cases of difficulty in breathing certainly does require the attention of one. You should therefore not hesitate to report to your physician for help if the side effects take longer than normal.
Other adverse drug reactions that might be associated with this drug include mouth pain, swelling and unexplainable tiredness or weakness. Moreover, patients who develop skin rashes and hives or severe muscle cramps after taking Clodronate should seek medical attention as a matter of urgency. Since these are just pre-release precautions, one should not be discouraged, as the final product may be a very stable product with lesser side effects.
Some general contraindications are common with most prescription drugs. For instance, you should not take the drug if you are allergic to Clodronates or bisphosphonates. Similarly, expecting or breastfeeding mothers should not use the drug. Patients with kidney problems or using other bisphosphonate drugs should not use the drug too. It is also advisable that you stay from these types of drugs if you have inflammation of the gastro intestines.
The use of clodronate liposome, like any other prescription medicine, should be a strict procedure. You are therefore not allowed to share it with other patients even if you suffer from the same disease. Additionally, you are not to borrow such drugs unless a qualified doctor prescribes them. Finally and yet importantly, you have to take the full dose without skipping if significant progress or complete healing is to be realized.
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